Non-steroidal anti-inflammatory agents and the gastrointestinal tract.

Non-steroidal anti-inflammatory agents and the gastrointestinal tract.

Non-Steroidal Anti-Inflammatory Drugs in the Carcinogenesis of the Gastrointestinal Tract

It is estimated that underlying infections and inflammatory responses are linked to 15-20% of all deaths from cancer worldwide. Inflammation is a physiologic process in response to tissue damage resulting from microbial pathogen infection, chemical irritation, and/or wounding. Tissues injured throughout the recruitment of inflammatory cells such as macrophages and neutrophils, generate a great ...

Non-steroidal anti-inflammatory drug toxicity in the upper gastrointestinal tract.

Non-steroidal anti-inflammatory drug (NSAID) toxicity in the upper gastrointestinal tract is the most common serious drug-induced toxicity reported to drug regulatory authorities. In the last two decades, the rediscovery of H. pylori, development of potent ulcer-healing drugs and specific Cox-II inhibitors have opened new horizons in the management of NSAID toxicity. A Working Party composed of...

The chemistry of non-steroidal anti-inflammatory agents.

It is not possible to discuss immediately the chemistry of, and the therapeutic response to, anti-inflammatory agents which do not possess the steroidal skeleton without properly defining the terms. It is even more fundamental, but entirely in order, to make some introductory remarks concerning those small molecules, normally dubbed 'drugs', which are designed to combat diseases of major import...

Peptic ulcer and non-steroidal anti-inflammatory agents.

Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and paracetamol in the aetiology of peptic ulcer is unclear. To investigate this we conducted a case control study of 180 matched pairs of peptic ulcer patients and controls obtained from surgical and dermatology outpatient clinics. There were 95 gastric ulcer and 85 duodenal ulcer p...